Excessive Fibrin Deposition in Nasal Polyps Caused by Fibrinolytic Impairment through Reduction of Tissue Plasminogen Activator Expression

Rationale: Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. Objectives: We hypothesized that formation of a fibrin mesh...

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Detalhes bibliográficos
Main Authors: Takabayashi, Tetsuji, Kato, Atsushi, Peters, Anju T., Hulse, Kathryn E., Suh, Lydia A., Carter, Roderick, Norton, James, Grammer, Leslie C., Cho, Seong H., Tan, Bruce K., Chandra, Rakesh K., Conley, David B., Kern, Robert C., Fujieda, Shigeharu, Schleimer, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570641/
https://ncbi.nlm.nih.gov/pubmed/23155140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201207-1292OC
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