Anti-cancer IAP Inhibition Increases Bone Metastasis via Unexpected Osteoclast Activation

IAP (inhibitor of apoptosis) proteins play a central role in many types of cancer, and IAP antagonists are in development as anti-cancer agents. IAP antagonists cause apoptosis in many cells, but they also activate alternative NF-κB signaling through NIK, which regulates osteoclasts. In bone metasta...

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Hlavní autoři: Yang, Chang, Davis, Jennifer L., Zeng, Rong, Vora, Paras, Su, Xinming, Collins, Lynne I., Vangveravong, Suwanna, Mach, Robert H., Piwnica-Worms, David, Weilbaecher, Katherine N., Faccio, Roberta, Novack, Deborah Veis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570610/
https://ncbi.nlm.nih.gov/pubmed/23269702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0271
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