WNK4 regulates apical and basolateral Cl(–) flux in extrarenal epithelia

Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with hyperkalemia. In the kidney, WNK4 regulates the balance between NaCl reabsorption and K(+) secretion via variable inhibition of the thiazide-sen...

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Detalhes bibliográficos
Main Authors: Kahle, Kristopher T., Gimenez, Ignacio, Hassan, Hatim, Wilson, Frederick H., Wong, Robert D., Forbush, Biff, Aronson, Peter S., Lifton, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC357052/
https://ncbi.nlm.nih.gov/pubmed/14769928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308434100
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