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WNK4 regulates apical and basolateral Cl(–) flux in extrarenal epithelia

Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with hyperkalemia. In the kidney, WNK4 regulates the balance between NaCl reabsorption and K(+) secretion via variable inhibition of the thiazide-sen...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Kahle, Kristopher T., Gimenez, Ignacio, Hassan, Hatim, Wilson, Frederick H., Wong, Robert D., Forbush, Biff, Aronson, Peter S., Lifton, Richard P.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC357052/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14769928/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308434100
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