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Loss of Function of the Mouse Sharpin Gene Results in Peyer’s Patch Regression
Peyer’s patches (PP) are an important component in the immune response against intestinal pathogens. Two independent, spontaneous mutations in the mouse Sharpin gene (Sharpin(cpdm) and Sharpin(cpdm-Dem)) result in the absence of PP and disrupted splenic white pulp in adult mice, although a full comp...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3570409/ https://ncbi.nlm.nih.gov/pubmed/23424624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055224 |
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