The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

Motivation: Fronto-temporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, also called motor neuron disease, MND) are severe neurodegenerative diseases that show considerable overlap at the clinical and cellular level. The most common single mutation in families with FTD or ALS has recently...

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Main Authors: Levine, Timothy P., Daniels, Rachel D., Gatta, Alberto T., Wong, Louise H., Hayes, Matthew J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2013
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Applications Notes
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570213/
https://ncbi.nlm.nih.gov/pubmed/23329412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts725
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