Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic

Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant that still hydrolyzes ATP, yet is selectively sensitized to an N(6)-substituted ADP analog that inhibit...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Provance, D. William, Gourley, Christopher R., Silan, Colleen M., Cameron, L. C., Shokat, Kevan M., Goldenring, James R., Shah, Kavita, Gillespie, Peter G., Mercer, John A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC357019/
https://ncbi.nlm.nih.gov/pubmed/14766983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305895101
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы