Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic

Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant that still hydrolyzes ATP, yet is selectively sensitized to an N(6)-substituted ADP analog that inhibit...

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Detalhes bibliográficos
Main Authors: Provance, D. William, Gourley, Christopher R., Silan, Colleen M., Cameron, L. C., Shokat, Kevan M., Goldenring, James R., Shah, Kavita, Gillespie, Peter G., Mercer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC357019/
https://ncbi.nlm.nih.gov/pubmed/14766983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305895101
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