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Computational design of water-soluble analogues of the potassium channel KcsA

Although the interiors of membrane and water-soluble proteins are similar in their physicochemical properties, membrane proteins differ in having larger fractions of hydrophobic residues on their exteriors. Thus, it should be possible to water-solubilize membrane proteins by mutating their lipid-con...

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Hlavní autoři: Slovic, Avram M., Kono, Hidetoshi, Lear, James D., Saven, Jeffery G., DeGrado, William F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC357012/
https://ncbi.nlm.nih.gov/pubmed/14766985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306417101
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