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Computational design of water-soluble analogues of the potassium channel KcsA
Although the interiors of membrane and water-soluble proteins are similar in their physicochemical properties, membrane proteins differ in having larger fractions of hydrophobic residues on their exteriors. Thus, it should be possible to water-solubilize membrane proteins by mutating their lipid-con...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC357012/ https://ncbi.nlm.nih.gov/pubmed/14766985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306417101 |
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