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Computational design of a water-soluble analog of phospholamban

Membrane proteins and water-soluble proteins share a similar core. This similarity suggests that it should be possible to water-solubilize membrane proteins by mutating only their lipid-exposed residues. We have developed computational tools to design water-soluble variants of helical membrane prote...

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Hlavní autoři: Slovic, Avram M., Summa, Christopher M., Lear, James D., DeGrado, William F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312418/
https://ncbi.nlm.nih.gov/pubmed/12538897
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