Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Notch signaling pathway activation is known to contribute to the pathogenesis of a spectrum of human malignancies, including T cell leukemia. However, recent studies have implicated the Notch pathway as a tumor suppressor in myeloproliferative neoplasms and several solid tumors. Here we report a nov...

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Autori principali: Lobry, Camille, Ntziachristos, Panagiotis, Ndiaye-Lobry, Delphine, Oh, Philmo, Cimmino, Luisa, Zhu, Nan, Araldi, Elisa, Hu, Wenhuo, Freund, Jacquelyn, Abdel-Wahab, Omar, Ibrahim, Sherif, Skokos, Dimitris, Armstrong, Scott A., Levine, Ross L., Park, Christopher Y., Aifantis, Iannis
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570103/
https://ncbi.nlm.nih.gov/pubmed/23359070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121484
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