Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by nonsteroidal anti-inflammatory drugs and aspirin in mice

BACKGROUND AND PURPOSE: Low doses of aspirin (acetylsalicylic acid; ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of gastrointestinal bleeding. GPBAR1 is a bile acid receptor expressed in the gastrointestinal tract. Here, we have investigated whether GPBAR1 was required f...

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Библиографические подробности
Главные авторы: Cipriani, Sabrina, Mencarelli, Andrea, Bruno, Angela, Renga, Barbara, Distrutti, Eleonora, Santucci, Luca, Baldelli, Franco, Fiorucci, Stefano
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570017/
https://ncbi.nlm.nih.gov/pubmed/22881598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02128.x
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