The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes

BACKGROUND AND PURPOSE: The class III PI3K inhibitor, 3-methyladenine (3-MA), is commonly used to selectively block autophagy. Recent findings suggest a strong relationship between autophagy and lipid turnover. Here, we explore the effect of 3-MA on adipocyte lipolysis. EXPERIMENTAL APPROACH: Assays...

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Hlavní autoři: Heckmann, Bradlee L, Yang, Xingyuan, Zhang, Xiaodong, Liu, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570012/
https://ncbi.nlm.nih.gov/pubmed/22817685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02110.x
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