The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo

BACKGROUND AND PURPOSE: The mechanisms of paraquat (PQ)-induced toxicity are poorly understood and PQ poisoning is often fatal due to a lack of effective antidotes. In this study we report the effects of N-[2-(2-methoxy-6H-dipyrido{2,3-a:3,2-e}pyrrolizin-11-yl)ethyl]-2-furamide (NMDPEF), a melatonin...

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Detalhes bibliográficos
Main Authors: Janda, Elzbieta, Parafati, Maddalena, Aprigliano, Serafina, Carresi, Cristina, Visalli, Valeria, Sacco, Iolanda, Ventrice, Domenica, Mega, Tiziana, Vadalá, Nuria, Rinaldi, Stefano, Musolino, Vincenzo, Palma, Ernesto, Gratteri, Santo, Rotiroti, Domenicantonio, Mollace, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers with Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570002/
https://ncbi.nlm.nih.gov/pubmed/22289031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01870.x
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