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Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells

Phosphorodiamidate morpholino oligomers (PMO) are neutrally charged, sequence-specific antisense agents that interfere with targeted gene expression. PMO have been shown to be highly specific and potent therapies after cellular uptake, yet methods to detect PMO in tissue and inside the cell are limi...

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Main Authors: Schnell, Frederick J., Crumley, Stacy L., Mourich, Dan V., Iversen, Patrick L.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569923/
https://ncbi.nlm.nih.gov/pubmed/23515175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/biores.2012.0276
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