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Probes for narcotic receptor mediated phenomena. 46. N-Substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide bridged phenylmorphans

Oxide-bridged phenylmorphans were conceptualized as topologically distinct, structurally rigid ligands with 3-dimensional shapes that could not be appreciably modified on interaction with opioid receptors. An enantiomer of the N-phenethyl-substituted ortho-f isomer was found to have high affinity fo...

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Dettagli Bibliografici
Autori principali: Li, Fuying, Deck, Jason A., Dersch, Christina M., Rothman, Richard B., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569853/
https://ncbi.nlm.nih.gov/pubmed/23168379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.10.041
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