Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)

Unconjugated bilirubin (UCB) causes encephalopathy in severely jaundiced neonates by damaging astrocytes and neurons. Astrocytes, which help defend the brain against cytotoxic insults, express the ATP-dependent transporter, multidrug resistance-associated protein 1 (Mrp1), which mediates export of o...

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Hlavní autoři: Gennuso, Florinda, Fernetti, Cristina, Tirolo, Cataldo, Testa, Nuccio, L'Episcopo, Francesca, Caniglia, Salvo, Morale, Maria Concetta, Ostrow, J. Donald, Pascolo, Lorella, Tiribelli, Claudio, Marchetti, Bianca
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC356974/
https://ncbi.nlm.nih.gov/pubmed/14983033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308452100
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