Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP-43 and FUS/TLS, and SMN, respectively. However, whether there is a shared defective mechanism in RNA metabolism common to these two diseases...

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Detalhes bibliográficos
Main Authors: Tsuiji, Hitomi, Iguchi, Yohei, Furuya, Asako, Kataoka, Ayane, Hatsuta, Hiroyuki, Atsuta, Naoki, Tanaka, Fumiaki, Hashizume, Yoshio, Akatsu, Hiroyasu, Murayama, Shigeo, Sobue, Gen, Yamanaka, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569639/
https://ncbi.nlm.nih.gov/pubmed/23255347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202303
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