Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP-43 and FUS/TLS, and SMN, respectively. However, whether there is a shared defective mechanism in RNA metabolism common to these two diseases...

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Bibliografiske detaljer
Main Authors: Tsuiji, Hitomi, Iguchi, Yohei, Furuya, Asako, Kataoka, Ayane, Hatsuta, Hiroyuki, Atsuta, Naoki, Tanaka, Fumiaki, Hashizume, Yoshio, Akatsu, Hiroyasu, Murayama, Shigeo, Sobue, Gen, Yamanaka, Koji
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569639/
https://ncbi.nlm.nih.gov/pubmed/23255347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202303
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