The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis

The etiology and progression of a variety of human malignancies are linked to the deregulation of receptor tyrosine kinases (RTKs). To define the role of RTK-dependent signals in various oncogenic processes, we have previously engineered RTK oncoproteins that recruit either the Shc or Grb2 adaptor p...

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Detalhes bibliográficos
Main Authors: Saucier, Caroline, Khoury, Hanane, Lai, Ka-Man Venus, Peschard, Pascal, Dankort, David, Naujokas, Monica A., Holash, Jocelyn, Yancopoulos, George D., Muller, William J., Pawson, Tony, Park, Morag
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC356953/
https://ncbi.nlm.nih.gov/pubmed/14983012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308065101
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