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Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53(null) Cell Lines

The carboxy-terminal truncated p53 alternative spliced isoforms, p53β and p53γ, are expressed at disparate levels in cancer and are suggested to influence treatment response and therapy outcome. However, their functional role in cancer remains to be elucidated. We investigated their individual funct...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Silden, Elisabeth, Hjelle, Sigrun M., Wergeland, Line, Sulen, André, Andresen, Vibeke, Bourdon, Jean-Christophe, Micklem, David R., McCormack, Emmet, Gjertsen, Bjørn Tore
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569410/
https://ncbi.nlm.nih.gov/pubmed/23409163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056276
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