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Conjugation of Spermine Enhances Cellular Uptake of the Stapled Peptide-Based Inhibitors of p53-Mdm2 Interaction

We report the first synthesis of the C-terminally spermine-conjugated stapled peptide-based inhibitors of the p53-Mdm2 interaction. Subsequent biological, biophysical and cellular uptake assays with the spermine-conjugated stapled peptides revealed that spermine conjugation minimally affects biologi...

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Detalhes bibliográficos
Main Authors: Muppidi, Avinash, Li, Xiaolong, Chen, Jiandong, Lin, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569039/
https://ncbi.nlm.nih.gov/pubmed/22047690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.009
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