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Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A

Following activation by G-protein-coupled receptor agonists, protein kinase C (PKC) modulates cardiac myocyte function by phosphorylation of intracellular targets including myofilament proteins cardiac troponin I (cTnI) and cardiac myosin binding protein C (cMyBP-C). Since PKC phosphorylation has be...

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Detalhes bibliográficos
Main Authors: Hinken, Aaron C., Hanft, Laurin M., Scruggs, Sarah B., Sadayappan, Sakthivel, Robbins, Jeffery, Solaro, R. John, McDonald, Kerry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568763/
https://ncbi.nlm.nih.gov/pubmed/22527640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10974-012-9294-9
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