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Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure-Function Predictions by Site-Directed Mutagenesis of a Non-Functional AHR()

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). While significant interspecies...

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Hlavní autoři: Fraccalvieri, Domenico, Soshilov, Anatoly A., Karchner, Sibel I., Franks, Diana G., Pandini, Alessandro, Bonati, Laura, Hahn, Mark E., Denison, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568667/
https://ncbi.nlm.nih.gov/pubmed/23286227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301457f
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