Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

The aryl hydrocarbon receptor (AhR) is a ligand-dependent, basic helix–loop–helix Per-Arnt-Sim (PAS)-containing transcription factor that can bind and be activated by structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Our previou...

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Bibliografiska uppgifter
Huvudupphovsmän: Pandini, Alessandro, Soshilov, Anatoly A., Song, Yujuan, Zhao, Jing, Bonati, Laura, Denison, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859071/
https://ncbi.nlm.nih.gov/pubmed/19456125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900259z
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