Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

Although many human cancers such as melanoma express tumor antigens recognized by T cells, host immune responses often fail to control tumor growth for as yet unexplained reasons. Here, we found a strong association between melanocyte expression of B7-H1 (PD-L1), an immune-inhibitory molecule, and t...

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Main Authors: Taube, Janis M., Anders, Robert A., Young, Geoffrey D., Xu, Haiying, Sharma, Rajni, McMiller, Tracee L., Chen, Shuming, Klein, Alison P., Pardoll, Drew M., Topalian, Suzanne L., Chen, Lieping
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568523/
https://ncbi.nlm.nih.gov/pubmed/22461641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003689
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