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Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

Bacteria develop resistance to many classes of antibiotics vertically, by engendering mutations in genes encoding transcriptional and translational apparatus. These severe adaptations affect global transcription, translation, and the correspondingly affected metabolism. Here, we characterize metabol...

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Detalhes bibliográficos
Main Authors: Derewacz, Dagmara K., Goodwin, Cody R., McNees, C. Ruth, McLean, John A., Bachmann, Brian O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568320/
https://ncbi.nlm.nih.gov/pubmed/23341601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218524110
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