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Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents
In vertebrates, the biosynthesis of steroid hormones is initiated by cytochrome P450 CYP11A1 which converts cholesterol to pregnenolone. We investigated whether some of the experimental and FDA-approved therapeutic agents alter the activity of CYP11A1 in the reconstituted system in vitro. We found t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568244/ https://ncbi.nlm.nih.gov/pubmed/23089212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2012.10.013 |
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