HIF-1α Overexpression in Ductal Carcinoma In Situ of the Breast in BRCA1 and BRCA2 Mutation Carriers

Recent studies have revealed that BRCA1 and BRCA2 germline mutation-related breast cancers show frequent overexpression of hypoxia inducible factor-1α (HIF-1α), the key regulator of the hypoxia response. However, the question remained whether hypoxia is a late stage bystander or a true carcinogeneti...

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Main Authors: van der Groep, Petra, van Diest, Paul J., Smolders, Yvonne H. C. M., Ausems, Margreet G. E. M., van der Luijt, Rob B., Menko, Fred H., Bart, Joost, de Vries, Elisabeth G. E., van der Wall, Elsken
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568038/
https://ncbi.nlm.nih.gov/pubmed/23409121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056055
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