miR-125b Functions as a Key Mediator for Snail-induced Stem Cell Propagation and Chemoresistance

Chemoresistance is a major obstacle in cancer treatment. Our previous studies have shown that miR-125b plays an important role in chemoresistance. Here we report a novel mechanism that up-regulation of miR-125b through Wnt signaling by Snail enriches cancer stem cells. Overexpression of Snail dramat...

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Bibliographic Details
Main Authors: Liu, Zixing, Liu, Hao, Desai, Shruti, Schmitt, David C., Zhou, Ming, Khong, Hung T., Klos, Kristine S., McClellan, Steven, Fodstad, Oystein, Tan, Ming
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567684/
https://ncbi.nlm.nih.gov/pubmed/23255607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.419168
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