Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

Paracrine signaling between pancreatic islet β-cells and α-cells has been proposed to play a role in regulating glucagon responses to elevated glucose and hypoglycemia. To examine this possibility in human islets, we used a metabolomic approach to trace the responses of amino acids and other potenti...

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Main Authors: Li, Changhong, Liu, Chengyang, Nissim, Itzhak, Chen, Jie, Chen, Pan, Doliba, Nicolai, Zhang, Tingting, Nissim, Ilana, Daikhin, Yevgeny, Stokes, David, Yudkoff, Marc, Bennett, Michael J., Stanley, Charles A., Matschinsky, Franz M., Naji, Ali
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567647/
https://ncbi.nlm.nih.gov/pubmed/23266825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385682
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