Elimination of K(ATP) Channels in Mouse Islets Results in Elevated [U-(13)C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt

Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was hypothesized that these defects are the consequence of impaired integration of amino acid, glucose, and energy metabolis...

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Opis bibliograficzny
Główni autorzy: Li, Changhong, Nissim, Itzhak, Chen, Pan, Buettger, Carol, Najafi, Habiba, Daikhin, Yevgeny, Nissim, Ilana, Collins, Heather W., Yudkoff, Marc, Stanley, Charles A., Matschinsky, Franz M.
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2008
Hasła przedmiotowe:
Metabolism and Bioenergetics
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427330/
https://ncbi.nlm.nih.gov/pubmed/18445600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709235200
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