Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets

Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser(21) in GSK3α and Ser(9) in GSK3β) in response to varied external stimuli. Recent work suggests that GSK3 functions as a negative regulator of platelet...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Moore, Samantha F., van den Bosch, Marion T. J., Hunter, Roger W., Sakamoto, Kei, Poole, Alastair W., Hers, Ingeborg
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567645/
https://ncbi.nlm.nih.gov/pubmed/23239877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.429936
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak