Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets

Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser(21) in GSK3α and Ser(9) in GSK3β) in response to varied external stimuli. Recent work suggests that GSK3 functions as a negative regulator of platelet...

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Bibliographische Detailangaben
Hauptverfasser: Moore, Samantha F., van den Bosch, Marion T. J., Hunter, Roger W., Sakamoto, Kei, Poole, Alastair W., Hers, Ingeborg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567645/
https://ncbi.nlm.nih.gov/pubmed/23239877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.429936
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