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Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

In many bacterial pathogens, the second messenger c-di-GMP stimulates the production of an exopolysaccharide (EPS) matrix to shield bacteria from assaults of the immune system. How c-di-GMP induces EPS biogenesis is largely unknown. Here, we show that c-di-GMP allosterically activates the synthesis...

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Hlavní autoři: Steiner, Samuel, Lori, Christian, Boehm, Alex, Jenal, Urs
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567491/
https://ncbi.nlm.nih.gov/pubmed/23202856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.315
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