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Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch are unclear. We showed recently that the unive...

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Pubblicato in:Sci Adv
Autori principali: Dubey, Badri N., Lori, Christian, Ozaki, Shogo, Fucile, Geoffrey, Plaza-Menacho, Ivan, Jenal, Urs, Schirmer, Tilman
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026420/
https://ncbi.nlm.nih.gov/pubmed/27652341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600823
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