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Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice
Genome-wide DNA demethylation, including the erasure of genome imprints, in primordial germ cells (PGCs) is a critical first step to creating a totipotent epigenome in the germ line. We show here that, contrary to the prevailing model emphasizing active DNA demethylation, imprint erasure in mouse PG...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
European Molecular Biology Organization
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567490/ https://ncbi.nlm.nih.gov/pubmed/23241950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.331 |
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