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DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress

DJ-1 deficiency is a cause of genetic Parkinson’s disease (PARK7 PD). In sporadic PD, however, DJ-1 is abundantly-expressed in reactive astrocytes. This may represent a compensatory protective response. In initial support of this hypothesis, we have shown in vitro that DJ-1 over-expressing astrocyte...

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Detalhes bibliográficos
Main Authors: Mullett, Steven J., Di Maio, Roberto, Greenamyre, J. Timothy, Hinkle, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567237/
https://ncbi.nlm.nih.gov/pubmed/23065353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-012-9904-4
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