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DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

Mutations that eliminate DJ-1 expression cause a familial form of Parkinson’s disease (PD). In sporadic PD, and many other neurodegenerative diseases, reactive astrocytes over-express DJ-1 whereas neurons maintain its expression at non-disease levels. Since DJ-1 has neuroprotective properties, and s...

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Hlavní autoři: Mullett, Steven J., Hinkle, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638760/
https://ncbi.nlm.nih.gov/pubmed/18930142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.09.013
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