Fine Mapping of Xq28: Both MECP2 and IRAK1 Contribute to Risk for Systemic Lupus Erythematosus in Multiple Ancestral Groups

OBJECTIVES: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the under...

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Main Authors: Kaufman, Kenneth M., Zhao, Jian, Kelly, Jennifer A., Hughes, Travis, Adler, Adam, Sanchez, Elena, Ojwang, Joshua O., Langefeld, Carl D., Ziegler, Julie T., Williams, Adrienne H., Comeau, Mary E., Marion, Miranda C., Glenn, Stuart B., Cantor, Rita M., Grossman, Jennifer M., Hahn, Bevra H., Song, Yeong Wook, Yu, Chack-Yung, James, Judith A., Guthridge, Joel M., Brown, Elizabeth E., Alarcón, Graciela S., Kimberly, Robert P., Edberg, Jeffrey C., Ramsey-Goldman, Rosalind, Petri, Michelle A., Reveille, John D., Vilá, Luis M., Anaya, Juan-Manuel, Boackle, Susan A., Stevens, Anne M., Freedman, Barry I., Criswell, Lindsey A., Pons-Estel, Bernardo A., Lee, Joo-Hyun, Lee, Ji-Seon, Chang, Deh-Ming, Scofield, R Hal, Gilkeson, Gary S., Merrill, Joan T., Niewold, Timothy B., Vyse, Timothy J., Bae, Sang-Cheol, Alarcón-Riquelme, Marta E., Jacob, Chaim O., Sivils, Kathy Moser, Gaffney, Patrick M., Harley, John B., Sawalha, Amr H., Tsao, Betty P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567234/
https://ncbi.nlm.nih.gov/pubmed/22904263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-201851
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