Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (tti(s450)), which harbo...

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Main Authors: Boglev, Yeliz, Badrock, Andrew P., Trotter, Andrew J., Du, Qian, Richardson, Elsbeth J., Parslow, Adam C., Markmiller, Sebastian J., Hall, Nathan E., de Jong-Curtain, Tanya A., Ng, Annie Y., Verkade, Heather, Ober, Elke A., Field, Holly A., Shin, Donghun, Shin, Chong H., Hannan, Katherine M., Hannan, Ross D., Pearson, Richard B., Kim, Seok-Hyung, Ess, Kevin C., Lieschke, Graham J., Stainier, Didier Y. R., Heath, Joan K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567153/
https://ncbi.nlm.nih.gov/pubmed/23408911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003279
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