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Improved Modeling of Side-Chain–Base Interactions and Plasticity in Protein–DNA Interface Design

Combinatorial sequence optimization for protein design requires libraries of discrete side-chain conformations. The discreteness of these libraries is problematic, particularly for long, polar side chains, since favorable interactions can be missed. Previously, an approach to loop remodeling where p...

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Detalles Bibliográficos
Main Authors: Thyme, Summer B., Baker, David, Bradley, Philip
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566986/
https://ncbi.nlm.nih.gov/pubmed/22426128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.03.005
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