Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations

BACKGROUND: There are no reliable markers of malignancy in phaeochromocytomas (PCC) and paragangliomas (PGL). We investigated the relevance of the mammalian target of rapamycin (mTOR)/AKT and hypoxic pathways as novel immunohistochemical markers of malignancy. METHODS: Tissue microarray blocks were...

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Bibliographic Details
Main Authors: Pinato, D J, Ramachandran, R, Toussi, S T K, Vergine, M, Ngo, N, Sharma, R, Lloyd, T, Meeran, K, Palazzo, F, Martin, N, Khoo, B, Dina, R, Tan, T M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566818/
https://ncbi.nlm.nih.gov/pubmed/23257898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.538
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