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Tandem aldehyde–alkyne–amine coupling/cycloisomerization: A new synthesis of coumarins

Cu-catalyzed A(3) coupling of ethoxyacetylene, pyrrolidine and salicylaldehydes led to a concomitant cycloisomerization followed by hydrolysis of the resultant vinyl ether to afford coumarins in a cascade process. The reaction proceeded through exclusive 6-endo-dig cyclization and is compatible with...

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Autori principali: Reddy, Maddi Sridhar, Thirupathi, Nuligonda, Haribabu, Madala
Natura: Artigo
Lingua:Inglês
Pubblicazione: Beilstein-Institut 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566765/
https://ncbi.nlm.nih.gov/pubmed/23400373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.21
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