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Age sensitizes the kidney to heme protein-induced acute kidney injury

Age increases the risk for ischemic acute kidney injury (AKI). We questioned whether a similar age-dependent injury occurs following exposure to hemoglobin, a known nephrotoxin. Old mice (∼16 mo old), but not young mice (∼6 mo old), when administered hemoglobin, exhibited marked elevation in blood u...

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Main Authors: Nath, Karl A., Grande, Joseph P., Farrugia, Gianrico, Croatt, Anthony J., Belcher, John D., Hebbel, Robert P., Vercellotti, Gregory M., Katusic, Zvonimir S.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566520/
https://ncbi.nlm.nih.gov/pubmed/23195679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00606.2012
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