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Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep

Amino acids and glucose acutely stimulate fetal insulin secretion. In isolated adult pancreatic islets, amino acids potentiate glucose-stimulated insulin secretion (GSIS), but whether amino acids have this same effect in the fetus is unknown. Therefore, we tested the effects of increased fetal amino...

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Hauptverfasser: Gadhia, Monika M., Maliszewski, Anne M., O'Meara, Meghan C., Thorn, Stephanie R., Lavezzi, Jinny R., Limesand, Sean W., Hay, William W., Brown, Laura D., Rozance, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566506/
https://ncbi.nlm.nih.gov/pubmed/23211516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00377.2012
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