Dacomitinib, an Irreversible Pan-ErbB Inhibitor Significantly Abrogates Growth in Head and Neck Cancer Models That Exhibit Low Response to Cetuximab

Aberrant epidermal growth factor (EGF) signaling is associated with tumor growth in squamous cell carcinoma of the head and neck in humans (HNSCC), and is a major focus of targeted therapy. Cetuximab, a monoclonal antibody against EGFR, has been successful at prolonging survival but has only a 10% t...

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Main Authors: Ather, Ferdows, Hamidi, Habib, Fejzo, Marlena S., Letrent, Stephen, Finn, Richard S., Kabbinavar, Fairooz, Head, Christian, Wong, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566064/
https://ncbi.nlm.nih.gov/pubmed/23405260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056112
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