Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin

The adverse side effects of doxorubicin, including cardiotoxicity and cancer treatment-related fatigue, have been associated with inflammatory cytokines, many of which are regulated by mitogen-activated protein kinases (MAPKs). ZAK is an upstream kinase of the MAPK cascade. Using mouse primary macro...

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Detalhes bibliográficos
Main Authors: Wong, John, Smith, Logan B., Magun, Eli A., Engstrom, Thomas, Kelley-Howard, Kirsten, Jandhyala, Dakshina M., Thorpe, Cheleste M., Magun, Bruce E., Wood, Lisa J.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566053/
https://ncbi.nlm.nih.gov/pubmed/23114643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22628
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