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Synthesis and Evaluation of a Backbone Biodegradable Multiblock HPMA Copolymer Nanocarrier for the Systemic Delivery of Paclitaxel

The performance and safety of current antineoplastic agents, particularly water-insoluble drugs, are still far from satisfactory. For example, the currently widely used Cremophor EL(®)-based paclitaxel (PTX) formulation exhibits pharmacokinetic concerns and severe side effects. Thus, the concept of...

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Detalles Bibliográficos
Main Authors: Zhang, Rui, Luo, Kui, Yang, Jiyuan, Sima, Monika, Sun, Yongen, Janát-Amsbury, Margit M., Kopeček, Jindřich
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565036/
https://ncbi.nlm.nih.gov/pubmed/23262201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.12.009
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