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Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork

The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: van Pel, Derek M., Stirling, Peter C., Minaker, Sean W., Sipahimalani, Payal, Hieter, Philip
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Genetics Society of America 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564987/
https://ncbi.nlm.nih.gov/pubmed/23390603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.112.004754
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